Caplacizumab-Yhdp
Caplacizumab-Yhdp is a von Willebrand factor (vWF) directed antibody fragment used to treat acquired thrombotic thrombocytopenic purpura (aTTP), a rare and life-threatening blood clotting disorder. It works by binding to vWF and preventing platelet aggregation, which helps reduce the risk of clot formation in small blood vessels. This medication is typically used in combination with plasma exchange therapy and immunosuppression.
Caplacizumab-Yhdp is a targeted therapy for acquired thrombotic thrombocytopenic purpura that prevents abnormal blood clotting by blocking von Willebrand factor.
Key facts at a glance
- RxNorm
- 2110604
- Generic
- Caplacizumab-Yhdp
- Class
- pin-variant
- Brands
- Cablivi
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acquired thrombotic thrombocytopenic purpura (aTTP) in adults, typically used in combination with plasma exchange and immunosuppressive therapy.
Caplacizumab-Yhdp is a humanized variable domain of a monoclonal antibody that binds to the A1 domain of von Willebrand factor (vWF), inhibiting the interaction between vWF and platelet glycoprotein Ib-IX-V receptor. This prevents platelet adhesion and aggregation, reducing microthrombi formation in small blood vessels.
Administered as subcutaneous injection. Carries increased risk of bleeding, including mucosal bleeding and bruising. Patients should be monitored for signs of bleeding. Should not be used in patients with underlying bleeding disorders. Treatment decisions should involve careful assessment of individual patient risk-benefit profile.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy