Capmatinib
Capmatinib is a targeted therapy medication that inhibits the MET kinase and is specifically used to treat adults with metastatic non-small cell lung cancer (NSCLC) that has MET exon 14 skipping mutations. This genetic mutation causes abnormal MET signaling that promotes cancer growth, which capmatinib helps to block.
Capmatinib is a MET kinase inhibitor used to treat MET-mutant non-small cell lung cancer.
Key facts at a glance
- ATC
- L01EP01
- RxNorm
- 2362165
- Generic
- Capmatinib
- Class
- atc-l01
- Brands
- Tabrecta
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Capmatinib is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a MET exon 14 skipping mutation. It is used as a targeted therapy based on biomarker testing for this specific genetic alteration.
Capmatinib is a kinase inhibitor that targets and blocks the MET receptor tyrosine kinase. MET exon 14 skipping creates a mutant protein missing its regulatory domain, which normally provides negative feedback. This deletion leads to uncontrolled MET signaling and increased cell proliferation. By inhibiting MET, capmatinib suppresses tumor growth driven by this mutation.
Capmatinib is taken orally twice daily. Common side effects may include peripheral edema, nausea, fatigue, and liver enzyme elevations. Patients should have their tumors tested for MET exon 14 skipping mutations prior to treatment. Regular monitoring of liver function is recommended during therapy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy