Carbenicillin Disodium
Carbenicillin Disodium is a broad-spectrum penicillin-type antibiotic that was historically used to treat serious gram-negative bacterial infections, particularly those caused by Pseudomonas aeruginosa and certain Enterobacteriaceae. It is administered intravenously and works by inhibiting bacterial cell wall synthesis. While it has been largely replaced by newer antibiotics with improved safety profiles, it remains available for specific clinical situations.
An older penicillin antibiotic used for serious gram-negative bacterial infections that is administered intravenously.
Key facts at a glance
- RxNorm
- 258332
- Generic
- Carbenicillin Disodium
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of serious infections caused by susceptible gram-negative bacteria, including Pseudomonas aeruginosa, Proteus species, and certain Enterobacter infections. Historically used for respiratory tract, urinary tract, skin, soft tissue, bone, joint, and bloodstream infections.
As a beta-lactam antibiotic, carbenicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing the cross-linking of peptidoglycan chains necessary for cell wall strength and rigidity, ultimately leading to bacterial cell death.
Contains high sodium content (approximately 4.7 mEq per gram), which may contribute to fluid overload in patients with heart failure or renal impairment. Like all penicillins, can cause allergic reactions including anaphylaxis. May cause bleeding complications due to platelet dysfunction. Requires dose adjustment in renal impairment. Has been largely superseded by agents with broader spectrum and better tolerability profiles.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy