Carbenoxolone Sodium
Carbenoxolone Sodium is a semi-synthetic derivative of glycyrrhizinic acid (a compound found in licorice root) used primarily for the treatment of gastric and duodenal ulcers. It works by increasing gastric mucus secretion and exerting anti-inflammatory effects on the gastric mucosa. Due to its mineralocorticoid-like side effects, its use has declined in favor of newer ulcer medications.
A licorice-derived medication for peptic ulcers that increases stomach mucus production, now less commonly used due to side effects.
Key facts at a glance
- RxNorm
- 2018
- Generic
- Carbenoxolone Sodium
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of gastric and duodenal ulcers; topical formulations have been used for mouth ulcers (aphthous stomatitis)
Increases gastric mucus secretion, prolongs the life of mucosal cells, and has anti-inflammatory properties on the gastric lining to promote ulcer healing
May cause sodium and water retention, potassium loss, hypertension, and edema due to aldosterone-like effects. Contraindicated in patients with heart failure, hypertension, and renal impairment. Electrolytes should be monitored during treatment. Largely replaced by H2 blockers and proton pump inhibitors in modern practice.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy