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Carbocaine With Neocobefrin is a brand-name local anesthetic injection combining mepivacaine with the vasoconstrictor levonordefrin. It is primarily used in dental procedures to induce local numbness and control bleeding during surgical and restorative treatments. The addition of the vasoconstrictor helps prolong the duration of anesthesia and reduce blood flow to the treatment area.
A local anesthetic combination used in dentistry to numb tissues and minimize bleeding during procedures.
Key facts at a glance
- RxNorm
- 1012782
- Generic
- Carbocaine With Neocobefrin
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for local and infiltrative anesthesia in dental procedures including extractions, root canals, fillings, and other surgical or restorative treatments where prolonged numbness and hemostasis are desired.
Mepivacaine blocks nerve conduction by inhibiting sodium channels in nerve fibers, preventing pain signals from reaching the brain. Levonordefrin causes local vasoconstriction, which reduces blood flow to the area, prolongs the anesthetic effect, and minimizes bleeding during procedures.
Should only be administered by qualified healthcare professionals. Contraindicated in patients with certain cardiovascular conditions, severe liver disease, or known allergies to amide-type anesthetics. Dosage must be carefully calculated based on patient weight and medical history to avoid toxicity. Intended for local/inregional use only, not for intravenous or spinal administration.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy