Cefamandole Nafate
Cefamandole Nafate is a second-generation cephalosporin antibiotic (pin-variant) used to treat various bacterial infections. It works against a broad range of gram-positive and gram-negative organisms. This medication has been largely replaced by safer alternatives due to significant side effects.
Cefamandole Nafate is a broad-spectrum cephalosporin antibiotic (pin-variant) for bacterial infections, now rarely used due to safety concerns.
Key facts at a glance
- RxNorm
- 20473
- Generic
- Cefamandole Nafate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for respiratory tract infections, urinary tract infections, skin and soft tissue infections, bone and joint infections, and septicemia caused by susceptible bacteria. Particularly active against gram-negative organisms and some gram-positive cocci.
As a beta-lactam antibiotic, it inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell death. The pin-variant designation refers to its specific molecular formulation.
Contraindicated in patients with cephalosporin or penicillin allergies. Known to cause disulfiram-like reactions with alcohol consumption and can prolong bleeding time through effects on platelet function. Monitor for signs of superinfection during prolonged therapy. Has been largely withdrawn from many markets due to bleeding complications and availability of safer alternatives.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy