Cefiderocol Sulfate Tosylate
Cefiderocol Sulfate Tosylate is a siderophore cephalosporin antibiotic used to treat serious gram-negative bacterial infections in adults when other options are limited. It is particularly effective against multi-drug resistant bacteria including carbapenem-resistant organisms. This medication is administered intravenously and is reserved for cases where other antibiotics may not be effective due to resistance.
A broad-spectrum cephalosporin antibiotic for treating multi-drug resistant gram-negative infections when other antibiotics fail.
Key facts at a glance
- RxNorm
- 2265863
- Generic
- Cefiderocol Sulfate Tosylate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of complicated urinary tract infections (cUTI), hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP) in adults when caused by susceptible gram-negative bacteria. Often used when infections are resistant to other antibiotic options.
Cefiderocol is a cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). It uniquely uses a siderophore-like mechanism, mimicking natural iron-chelating compounds to actively transport itself into gram-negative bacterial cells, allowing it to overcome permeability barriers that typically resist antibiotic penetration.
Administered via intravenous infusion typically over 3 hours. Requires dose adjustment in patients with renal impairment. May cause adverse effects including diarrhea, constipation, nausea, and rash. Allergic reactions possible in patients with cephalosporin or penicillin hypersensitivity. Used when susceptibility testing indicates limited treatment options due to resistance patterns.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy