Cefoperazone Sodium
Cefoperazone Sodium is a third-generation cephalosporin antibiotic with broad-spectrum activity against gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa. It is typically used to treat serious infections including intra-abdominal infections, urinary tract infections, and respiratory tract infections. The medication is administered intravenously or intramuscularly and is often reserved for moderate to severe bacterial infections.
Cefoperazone Sodium is a broad-spectrum cephalosporin antibiotic used to treat serious bacterial infections, particularly those caused by gram-negative organisms.
Key facts at a glance
- RxNorm
- 227214
- Generic
- Cefoperazone Sodium
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of infections caused by susceptible gram-negative bacteria including intra-abdominal infections, urinary tract infections, respiratory tract infections, skin and soft tissue infections, and gonorrhea. May be used for infections of the biliary tract and bone/joint infections.
As a beta-lactam antibiotic, cefoperazone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to disruption of the peptidoglycan layer and bacterial cell death.
Use with caution in patients with penicillin allergy (cross-reactivity possible). May cause bleeding problems due to vitamin K deficiency, especially with prolonged use. Contains sodium and may cause diarrhea. Requires dose adjustment in hepatic impairment. Monitor for superinfection and Clostridioides difficile infection.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy