Cenegermin
Cenegermin is a recombinant human nerve growth factor (rhNGF) ophthalmic solution used to treat neurotrophic keratitis, a rare degenerative corneal disease. It works by supporting the survival and maintenance of corneal nerves, promoting corneal healing and reducing the risk of ulcers and perforation.
Cenegermin is a nerve growth factor eye drop for treating neurotrophic keratitis by regenerating corneal nerves.
Key facts at a glance
- ATC
- S01XA24
- RxNorm
- 2104332
- Generic
- Cenegermin
- Class
- atc-s01
- Brands
- Oxervate
- Availability
- rx
- Lactation
- unknown
- Routes
- ophthalmic
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe neurotrophic keratitis in adults, a rare condition characterized by impaired corneal healing due to decreased corneal sensitivity and nerve dysfunction.
Contains recombinant human nerve growth factor that binds to high-affinity TrkA and low-affinity p75NTR receptors in the anterior segment of the eye, supporting neuronal differentiation, maintenance, and survival to promote corneal healing.
Administered as eye drops, typically 6-8 times daily for 8 weeks. Common side effects include eye pain, hyperemia, and tearing. Should be used under specialist supervision and requires refrigeration. Contraindicated in patients with known hypersensitivity to the active substance or excipients.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy