Cenobamate
Cenobamate is an antiepileptic medication used as adjunctive treatment for adults with partial-onset (focal) seizures. It works by reducing repetitive neuronal firing through inhibition of voltage-gated sodium channels and positive allosteric modulation of GABA receptors, helping to decrease seizure frequency.
Cenobamate is an antiepileptic drug for partial-onset seizures that works by inhibiting sodium channels and enhancing GABA activity.
Key facts at a glance
- ATC
- N03AX25
- RxNorm
- 2265690
- Generic
- Cenobamate
- Class
- atc-n03
- Brands
- Xcopri
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Adjunctive treatment of partial-onset seizures in adults with epilepsy. It is typically prescribed when other antiepileptic medications have not adequately controlled seizure activity.
Cenobamate exerts its effects through dual mechanisms: it inhibits voltage-gated sodium currents to reduce repetitive neuronal firing, and it acts as a positive allosteric modulator of GABA-A receptors to enhance inhibitory signaling in the brain.
As an antiepileptic, cenobamate should be initiated at a low dose and titrated gradually to reduce the risk of adverse effects. Common side effects may include dizziness, somnolence, and fatigue. Patients should follow their healthcare provider's dosing instructions carefully and report any unusual symptoms or worsening of seizures.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy