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Cephalothin Sodium

Published: July 26, 2026Updated: August 25, 2026

Cephalothin Sodium is a first-generation cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis. It was historically used to treat various bacterial infections, particularly those caused by gram-positive organisms, though it has largely been replaced by more stable cephalosporin derivatives in clinical practice.

Quick summary

A first-generation cephalosporin antibiotic used for bacterial infections, now largely replaced by newer agents.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

RxNorm
9860
Generic
Cephalothin Sodium
Class
pin-variant
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Used to treat various bacterial infections including respiratory tract infections, skin and soft tissue infections, urinary tract infections, and bone/joint infections caused by susceptible organisms.

As a beta-lactam antibiotic, it inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell death in susceptible bacteria.

Cross-reactivity with penicillin allergies may occur. Requires appropriate culture and sensitivity testing before use. Largely historical in modern practice due to the availability of more stable, better-tolerated alternatives. Must be reconstituted before parenteral administration.

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy