Cetylpyridinium Chloride
Cetylpyridinium Chloride is a quaternary ammonium compound with broad-spectrum antiseptic and antimicrobial properties. It is commonly used in oral care products such as mouthwashes and lozenges to reduce dental plaque, gingivitis, and minor mouth and throat infections. This medication is available in various topical and oral formulations for both prescription and over-the-counter use.
Cetylpyridinium Chloride is an antiseptic medication used primarily in oral care products to reduce plaque, treat gingivitis, and provide antimicrobial protection for the mouth and throat.
Key facts at a glance
- RxNorm
- 2287
- Generic
- Cetylpyridinium Chloride
- Class
- pin-variant
- Brands
- Colgate Total Mouthwash, Bucalsep, Orasep Reformulated Dec 2013, DuoCare Clinical, Crest Mouthwash, Cepacol Antibacterial Mouthwash
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Cetylpyridinium Chloride is indicated for the temporary relief of minor mouth and throat irritation, reduction of dental plaque and gingivitis when used in oral rinses, and as an antiseptic component in lozenges and throat sprays. It may also be used as a preservative in certain pharmaceutical formulations.
As a cationic surfactant and quaternary ammonium compound, Cetylpyridinium Chloride exerts its antimicrobial effect by disrupting the cell membrane of microorganisms. This action causes leakage of cellular contents and ultimately leads to cell death, providing broad-spectrum activity against bacteria and certain fungi.
For oral rinses, typically swish and spit without swallowing. May cause temporary staining of teeth or dental restorations with prolonged use. Avoid use in individuals with known hypersensitivity to quaternary ammonium compounds. Not recommended for children under 6 years unless directed by a healthcare provider. Consult a healthcare professional before use if pregnant, breastfeeding, or if symptoms persist beyond 7 days.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy