Cevimeline
Cevimeline is a cholinergic agonist that stimulates salivary gland secretion to treat dry mouth (xerostomia) in patients with Sjögren's syndrome. It works by activating muscarinic M1 and M3 receptors on salivary glands, increasing saliva production. This medication is typically taken three times daily and may also increase tear production in some patients.
Cevimeline is a prescription medication used to treat dry mouth in patients with Sjögren's syndrome by stimulating saliva production.
Key facts at a glance
- ATC
- N07AX03
- RxNorm
- 44281
- Generic
- Cevimeline
- Class
- atc-n07
- Brands
- Evoxac
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Cevimeline is FDA-approved for treating dry mouth (xerostomia) in patients with Sjögren's syndrome. It may also help increase tear production in some patients. The medication is typically prescribed when natural saliva production is significantly reduced, which can cause difficulty swallowing, speaking, and increased risk of dental decay.
Cevimeline works as a selective muscarinic receptor agonist, primarily activating M1 and M3 receptors on salivary glands. This stimulation triggers increased secretion of saliva, helping restore moisture in the mouth. The medication has a higher affinity for M1 receptors compared to M3 receptors.
Cevimeline is contraindicated in patients with uncontrolled asthma, iris closure (narrow-angle) glaucoma, or known hypersensitivity to the drug. Common side effects include excessive sweating, nausea, runny nose, and flushing. Patients with cardiovascular disease, asthma, or bladder obstruction should use this medication with caution. Regular monitoring of vital signs and oral health is recommended during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy