Chenodiol
Chenodal (chenodeoxycholic acid) is a naturally occurring bile acid used primarily to treat certain types of gallstones and cerebrotendinous xanthomatosis (CTX), a rare genetic disorder. It works by reducing cholesterol secretion into bile, which helps dissolve cholesterol-based gallstones in patients who are not candidates for surgery.
Chenodal is a bile acid medication used to dissolve cholesterol gallstones and treat the rare genetic condition cerebrotendinous xanthomatosis.
Key facts at a glance
- RxNorm
- 877414
- Generic
- Chenodal
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Chenodal is primarily used to treat radiolucent (non-calcified) cholesterol gallstones in patients who cannot undergo surgery, and it is also approved for cerebrotendinous xanthomatosis (CTX), a rare inherited disorder characterized by abnormal lipid accumulation in tissues.
As a bile acid, Chenodal reduces cholesterol secretion into bile and may inhibit intestinal cholesterol absorption, creating a bile composition that helps dissolve existing cholesterol gallstones over time. In CTX, it helps reduce the accumulation of cholestanol, a cholesterol-like substance that causes tissue damage.
Chenodal is available only through a restricted distribution program due to potential hepatotoxicity. Regular liver function monitoring is required during treatment. It is contraindicated in patients with known liver disease, bile duct obstruction, or radiopaque stones. Common side effects may include diarrhea and elevated liver enzymes.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy