Chlophedianol
Chlophedianol is a centrally acting antitussive medication used to temporarily relieve coughing. It works by suppressing the cough reflex in the brain, making it particularly useful for dry, non-productive coughs. This medication is typically prescribed for short-term relief of irritating coughs associated with minor upper respiratory conditions.
Chlophedianol is a cough suppressant used to relieve dry, irritating coughs.
Key facts at a glance
- ATC
- R05DA04
- RxNorm
- 2116
- Generic
- Chlophedianol
- Class
- atc-r05
- Brands
- Ninjacof, Ninjacof A, Vanacof AC
- Availability
- otc
- Pregnancy
- C
- Lactation
- unknown
- Half-life (h)
- 12
- Onset (min)
- 30
- Duration (h)
- 6
- Routes
- oral
- Forms
- oral liquid, syrup, oral solution
- Regions
- United States
- Monitoring
- none
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
11 groupspregnancy
first trimesteravoid if possible
use only if clearly needed and benefits outweigh potential risks to fetus
regular prenatal monitoring
Use with caution and monitor for adverse effects.
pregnancy
second trimesteravoid if possible
use only if benefits outweigh risks
routine prenatal care
Use with caution and monitor for adverse effects.
pregnancy
third trimesteravoid close to delivery
avoid use near term unless absolutely necessary
fetal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedinguse with caution
discontinue breastfeeding or avoid drug; excretion in breast milk unknown
monitor infant for drowsiness or feeding changes
Use with caution and monitor for adverse effects.
pediatric_age
under 2 yearsnot recommended
do not use in infants under 2 years due to risk of respiratory depression
respiratory monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
2 12 yearsweight-based dosing required
use only under physician supervision; do not exceed recommended pediatric dose
monitor for sedation and respiratory changes
Use with caution and monitor for adverse effects.
geriatric
elderlystart with lower dose
use with caution due to increased sensitivity to CNS effects; monitor for dizziness and sedation
monitor for falls, confusion, respiratory depression
Use with caution and monitor for adverse effects.
renal_impairment
mildno adjustment needed
use standard dosing with monitoring
monitor renal function periodically
Use with caution and monitor for adverse effects.
renal_impairment
moderate severereduce dose or increase interval
use with caution; consider dose reduction in severe impairment
monitor renal function and drug accumulation
Use with caution and monitor for adverse effects.
hepatic_impairment
mild moderateuse with caution
use lower initial dose; monitor for increased CNS effects
monitor liver function and for signs of toxicity
Use with caution and monitor for adverse effects.
hepatic_impairment
severesignificant dose reduction
avoid or use minimal effective dose; contraindicated in severe hepatic impairment if alternatives available
close monitoring for drug accumulation and CNS depression
Use with caution and monitor for adverse effects.
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information - cough suppressant
Common uses
Common therapeutic uses
Regulatory status in US
Current availability status
Temporary relief of non-productive (dry) cough associated with minor upper respiratory infections, allergies, or irritants. Not intended for productive coughs where mucus should be expelled.
Acts centrally on the brain's cough center to suppress the cough reflex. This reduces the frequency and intensity of coughing without affecting the respiratory system.
May cause drowsiness; avoid operating machinery or driving until effects are known. Use only as directed for short-term treatment. Consult a healthcare provider if cough persists beyond 7 days, worsens, or is accompanied by fever, rash, or persistent headache. Not recommended for children unless specifically directed by a pediatrician.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy