Chloral Hydrate
Chloral Hydrate is a sedative and hypnotic medication historically used for the short-term treatment of insomnia and as a sedative before medical procedures. It works by depressing the central nervous system to produce drowsiness and promote sleep. Due to safety concerns and the availability of safer alternatives, its use has declined significantly.
A historical sedative-hypnotic medication used for insomnia and procedural sedation, now largely replaced by safer options.
Key facts at a glance
- RxNorm
- 2344
- Generic
- Chloral Hydrate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Short-term treatment of insomnia, preoperative sedation, and sedation for diagnostic procedures. Its use has become limited due to safety concerns.
Acts as a central nervous system depressant. It is metabolized to trichloroethanol, which produces sedative and hypnotic effects through enhancement of GABAergic signaling in the brain.
Has a narrow therapeutic index with risk of overdose. May cause gastrointestinal irritation, tolerance, dependence, and potentially serious cardiac effects. Not recommended for long-term use. Use with caution in elderly and pediatric patients due to paradoxical reactions and safety concerns.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy