Chlormethiazole
Chlormethiazole is a sedating medication historically used as a hypnotic for the short-term treatment of insomnia and as an agent for managing alcohol withdrawal symptoms. It works by enhancing the effects of GABA, an inhibitory neurotransmitter in the brain, producing a calming effect on the central nervous system.
A sedating medication used primarily for insomnia and alcohol withdrawal management.
Key facts at a glance
- ATC
- N05CM02
- RxNorm
- 2372
- Generic
- Chlormethiazole
- Class
- atc-n05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Short-term treatment of insomnia and management of alcohol withdrawal symptoms, including prevention of seizures. It has also been used as a pre-anesthetic sedative.
Enhances GABAergic transmission in the central nervous system by binding to a distinct site on the GABA-A receptor complex, increasing inhibitory signaling and producing sedative, anxiolytic, and anticonvulsant effects.
Use has declined in many countries due to availability of safer alternatives. May cause drowsiness, dependency with prolonged use, and should be used with caution in patients with respiratory impairment. Not recommended for long-term use.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy