Chloroquine Diphosphate
Chloroquine Diphosphate (R)- is the right-handed stereoisomer of the antimalarial agent chloroquine. It exhibits antimalarial activity against susceptible Plasmodium species and also possesses anti-inflammatory and immunomodulatory properties. While historically used for malaria prophylaxis and treatment of autoimmune conditions, its therapeutic applications have evolved with emerging resistance patterns and changing clinical guidelines.
An antimalarial and anti-inflammatory agent used primarily for malaria treatment and prevention, with the (R)-enantiomer representing one specific stereoisomer of the racemic chloroquine compound.
Key facts at a glance
- RxNorm
- 2593903
- Generic
- Chloroquine Diphosphate, (R)-
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of malaria caused by susceptible Plasmodium species, including P. vivax, P. malariae, and P. ovale. Has been investigated for autoimmune conditions such as lupus and rheumatoid arthritis, though use varies by region and current guidelines.
The (R)-enantiomer accumulates in acidic vacuoles of parasites, inhibiting heme polymerase and causing accumulation of toxic heme. It may also exert anti-inflammatory effects through modulation of immune responses and inhibition of toll-like receptor signaling.
Resistance to chloroquine is widespread in P. falciparum, limiting its use in many regions. The (R)-enantiomer may exhibit different pharmacokinetic and pharmacodynamic profiles compared to the (S)-form. Requires careful monitoring for potential cardiac and ocular toxicity. Should only be used under medical supervision with appropriate diagnostic confirmation of infection.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy