Chlorpheniramine Maleate
Chlorpheniramine Maleate is a first-generation antihistamine used to relieve allergy symptoms such as runny nose, sneezing, itchy/watery eyes, and skin rashes like hives or itching. It works by blocking histamine H1 receptors, reducing allergic reactions throughout the body. This medication is available over-the-counter and by prescription in various forms including tablets, capsules, liquids, and injections.
Chlorpheniramine Maleate is an antihistamine that treats allergy symptoms by blocking histamine receptors in the body.
Key facts at a glance
- RxNorm
- 142429
- Generic
- Chlorpheniramine Maleate
- Class
- pin-variant
- Brands
- Zodryl DAC, Zodryl AC, Chlor-Trimeton, Tuxarin, Aller-Chlor, Clorrelief, Poly Hist PD, Wal-finate
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats seasonal and perennial allergic rhinitis (hay fever), allergic conjunctivitis, urticaria (hives), pruritus (itching), mild allergic reactions, and provides relief from common cold symptoms including runny nose and sneezing.
This medication blocks H1 histamine receptors in the body, preventing histamine from binding and causing allergic symptoms like itching, swelling, mucus production, and vasodilation that lead to runny nose and watery eyes.
As a first-generation antihistamine, it causes significant drowsiness and should be used with caution when driving or operating machinery. Avoid alcohol and other CNS depressants. Use caution in elderly patients, those with glaucoma, urinary retention, or thyroid disorders. Not recommended for newborn infants or premature babies. May interact with MAO inhibitors and other sedating medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy