Chlorpheniramine Polistirex
Chlorpheniramine Polistirex is an extended-release first-generation antihistamine that provides relief from allergy symptoms such as sneezing, runny nose, itchy eyes, and skin irritation. The polistirex delivery system allows for gradual, sustained release of the medication over approximately 12 hours, offering longer-lasting relief compared to immediate-release formulations.
Extended-release antihistamine for temporary relief of allergies and cold symptoms.
Key facts at a glance
- RxNorm
- 221074
- Generic
- Chlorpheniramine Polistirex
- Class
- pin-variant
- Brands
- Tuzistra, Tussionex
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats seasonal and perennial allergic rhinitis, hay fever symptoms, allergic skin reactions including urticaria (hives), and common cold symptoms like sneezing and runny nose.
Blocks histamine H1 receptors in the body, preventing histamine from binding and causing allergic symptoms. As a first-generation antihistamine, it also has anticholinergic properties that help reduce nasal secretions and other parasympathetic symptoms.
May cause drowsiness, dry mouth, and blurred vision. Avoid alcohol and operating machinery until knowing how medication affects you. Use caution in elderly patients due to increased sensitivity to anticholinergic effects. Consult healthcare provider before use if pregnant, breastfeeding, or taking other medications, especially sedatives or MAO inhibitors.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy