Chlorproethazine Hydrochloride
Chlorproethazine Hydrochloride is a first-generation phenothiazine antipsychotic medication that was used primarily for the treatment of psychotic disorders and severe mental health conditions. It belongs to a class of medications known for their tranquilizing effects on the central nervous system.
A phenothiazine antipsychotic used for managing psychotic symptoms and related psychiatric conditions.
Key facts at a glance
- RxNorm
- 236297
- Generic
- Chlorproethazine Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for management of psychotic disorders and schizophrenia; historically employed as a neuroleptic agent for conditions requiring sedation and behavioral control. Less commonly used today compared to newer atypical antipsychotics.
Works by blocking dopamine receptors in the brain, particularly D2 receptors, which helps reduce dopamine-mediated signaling associated with psychotic symptoms. Also exhibits antihistaminic and anticholinergic properties.
This is an older typical antipsychotic with more side effects than modern alternatives. May cause sedation, extrapyramidal symptoms, orthostatic hypotension, and anticholinergic effects. Use has declined significantly in favor of newer agents with improved side effect profiles. Prescription only medication requiring careful monitoring.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy