Chlorpropamide
Chlorpropamide is a first-generation sulfonylurea medication used to manage type 2 diabetes mellitus by stimulating the pancreas to release more insulin, which helps lower blood glucose levels.
An older sulfonylurea that lowers blood sugar by stimulating insulin release from the pancreas, used for type 2 diabetes management.
Key facts at a glance
- ATC
- A10BB02
- RxNorm
- 2404
- Generic
- Chlorpropamide
- Class
- atc-a10
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Management of type 2 diabetes mellitus in patients who have not achieved adequate glycemic control through diet and exercise alone. Historically, it has also been used off-label for diabetes insipidus due to its antidiuretic effects.
Chlorpropamide binds to and closes ATP-sensitive potassium channels on pancreatic beta cells. This causes depolarization of the cell membrane and opens voltage-gated calcium channels, leading to increased calcium influx that triggers insulin secretion.
This medication carries a significant risk of hypoglycemia, particularly in elderly patients and those with impaired renal function. It may also cause weight gain, hyponatremia, and alcohol intolerance. Due to its long half-life and higher side effect profile compared to newer sulfonylureas, it is now rarely prescribed as a first-line treatment for type 2 diabetes.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy