Chlorprothixene Hydrochloride
Chlorprothixene Hydrochloride is a first-generation antipsychotic medication belonging to the thioxanthene class. It is primarily used to treat schizophrenia and other psychotic disorders, as well as severe anxiety and agitation. The medication works by blocking dopamine receptors in the brain, helping to reduce psychotic symptoms such as hallucinations, delusions, and disorganized thinking.
Chlorprothixene Hydrochloride is an antipsychotic used to treat schizophrenia and psychotic disorders by blocking dopamine receptors in the brain.
Key facts at a glance
- RxNorm
- 91133
- Generic
- Chlorprothixene Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to treat schizophrenia, schizoaffective disorders, other psychotic conditions, severe anxiety, and behavioral disturbances. May also be used for nausea and vomiting in some cases.
Functions primarily as a dopamine D2 receptor antagonist, reducing dopaminergic transmission in the mesolimbic pathway. Also exhibits antagonist activity at alpha-adrenergic, muscarinic acetylcholine, and histamine H1 receptors, contributing to its sedative and anticholinergic effects.
May cause significant sedation, orthostatic hypotension, and anticholinergic side effects. Requires monitoring for tardive dyskinesia and neuroleptic malignant syndrome. Use with caution in patients with cardiovascular disease, seizures, or narrow-angle glaucoma. May interact with other CNS depressants and anticholinergic medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy