Cholic Acid
Cholbam (cholic acid) is a prescription brand-name bile acid replacement therapy used to treat bile acid synthesis disorders caused by single enzyme defects and as adjunctive treatment for peroxisomal disorders (such as Zellweger spectrum disorders) with liver disease manifestations. It works by replacing deficient bile acids to improve fat and fat-soluble vitamin absorption, while providing negative feedback to reduce toxic bile acid production.
Cholbam is a specialized bile acid replacement for rare metabolic and peroxisomal disorders affecting bile acid synthesis and fat absorption.
Key facts at a glance
- RxNorm
- 1608269
- Generic
- Cholbam
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of bile acid synthesis disorders due to single enzyme defects in adults and children. Adjunctive therapy for peroxisomal disorders (Zellweger spectrum) in patients with liver disease, steatorrhea, or fat-soluble vitamin malabsorption complications.
Cholbam replaces deficient primary bile acids, improving fat and fat-soluble vitamin absorption while suppressing toxic bile acid accumulation through negative feedback on hepatic synthesis pathways.
Brand-name only medication with no generic available. Requires specialist supervision with regular liver function monitoring. Patients with known bile duct obstruction should not use this medication. Dosage is weight-based and typically taken with food.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy