Cisapride
Cisapride is a prokinetic agent that enhances digestive tract motility by increasing acetylcholine release, primarily used to treat gastroesophageal reflux disease (GERD).
A prokinetic medication for GI motility disorders, now largely withdrawn due to cardiac safety concerns.
Key facts at a glance
- ATC
- A03FA02
- RxNorm
- 35255
- Generic
- Cisapride
- Class
- atc-a03
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of gastroesophageal reflux disease (GERD), gastroparesis, functional dyspepsia, and chronic constipation when other treatments have failed.
Acts as a serotonin 5-HT4 receptor agonist to enhance acetylcholine release in the enteric nervous system, increasing gastric contractions and accelerating gastric emptying.
Withdrawn from most markets in 2000 due to serious cardiac arrhythmias including QT prolongation and torsades de pointes. Contraindicated with CYP3A4 inhibitors and in patients with existing QT prolongation or cardiac disease. Requires cardiac monitoring when used.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy