Cisapride Monohydrate
Cisapride Monohydrate is a gastrointestinal prokinetic agent that enhances stomach and intestinal motility. It was historically used to treat conditions involving delayed gastric emptying, such as gastroesophageal reflux disease (GERD) and gastroparesis, by increasing the movement of food through the digestive tract.
A prokinetic medication formerly used to improve GI motility in reflux and gastric emptying disorders, now largely withdrawn due to cardiac safety concerns.
Key facts at a glance
- RxNorm
- 221077
- Generic
- Cisapride Monohydrate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for gastroesophageal reflux disease (GERD) and gastroparesis (delayed stomach emptying), as well as constipation related to GI motility issues.
Functions as a 5-HT4 receptor agonist that increases acetylcholine release in the gastrointestinal tract, thereby enhancing gastric motility and accelerating stomach emptying.
This medication has been withdrawn from markets in many countries due to serious cardiac risks, including QT prolongation and potentially fatal arrhythmias. It should only be used under strict medical supervision where available, and is contraindicated with many common medications that also affect heart rhythm.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy