Citrulline Malate
Citrulline Malate is a compound combining the amino acid L-citrulline with malic acid, commonly used as a dietary supplement for exercise performance and endurance support. It is utilized by athletes and active individuals seeking to reduce fatigue and improve recovery, and may also be used in certain cardiovascular and metabolic health contexts.
Citrulline Malate is an amino acid compound used to support exercise performance, reduce fatigue, and enhance blood flow.
Key facts at a glance
- RxNorm
- 2707558
- Generic
- Citrulline Malate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used as a sports nutrition supplement to support exercise performance, reduce muscle fatigue, and improve recovery. May also be used for cardiovascular support and in conditions involving impaired nitric oxide production.
Citrulline is converted to arginine in the kidneys, which then promotes the production of nitric oxide. Nitric oxide helps dilate blood vessels, improving blood flow, oxygen delivery to muscles, and removal of metabolic waste products like ammonia that contribute to fatigue.
Generally well-tolerated, but may cause gastrointestinal discomfort in some individuals. Available in both oral supplement and injectable forms. Those with citrullinemia or severe liver/kidney impairment should avoid use. Consult a healthcare provider before combining with blood pressure or erectile dysfunction medications due to potential additive effects.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy