Estradiol
Climara is a prescription estrogen hormone replacement medication delivered through a weekly transdermal patch. It contains estradiol, a form of estrogen, and is primarily used to treat moderate to severe menopausal symptoms such as hot flashes and vaginal dryness. This medication is designed for women who have not had a hysterectomy, as the estrogen-only formulation may not be suitable for those with an intact uterus without additional progestogen therapy.
Climara is an estrogen-only weekly patch used to treat menopausal symptoms by replacing declining hormone levels.
Key facts at a glance
- RxNorm
- 323984
- Generic
- Climara
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe vasomotor symptoms (hot flashes and night sweats) associated with menopause, treatment of moderate to severe symptoms of vulvar and vaginal atrophy, and prevention of postmenopausal osteoporosis.
Climara delivers estradiol, a synthetic form of estrogen, through the skin into the bloodstream. It replaces the estrogen that the ovaries produce less of during menopause, helping to restore hormone levels and alleviate menopausal symptoms.
Applied as a transdermal patch once weekly to the lower abdomen. Patients with an intact uterus may require additional progestogen therapy to reduce endometrial cancer risk. Estrogen therapy carries risks including increased risk of stroke, blood clots, and certain cancers. Should not be used by pregnant women or those with certain health conditions. Consult your healthcare provider for personalized medical advice.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy