Clobazam
Clobazam is a 1,5-benzodiazepine medication primarily used as an adjunctive treatment for seizures, including Lennox-Gastaut syndrome. It works by enhancing the effects of GABA, a calming neurotransmitter in the brain, which helps reduce seizure activity and anxiety.
Clobazam is an anti-seizure benzodiazepine that enhances GABA activity in the brain.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N05BA09
- RxNorm
- 21241
- Generic
- Clobazam
- Class
- atc-n05
- Brands
- Onfi, Sympazan
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Clobazam is FDA-approved as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in patients 2 years and older. It may also be used off-label for other seizure types, anxiety disorders, and muscle spasms.
Clobazam binds to the benzodiazepine site on GABA A receptors, potentiating GABAergic neurotransmission. This enhances the inhibitory effects of GABA, resulting in decreased neuronal excitability and seizure suppression.
Clobazam is a Schedule IV controlled substance with potential for dependence and tolerance with prolonged use. Common side effects include drowsiness, fatigue, and coordination difficulties. It should not be discontinued abruptly, as withdrawal symptoms may occur. Alcohol and other CNS depressants may enhance sedation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy