Clodronate Disodium
Clodronate Disodium is a bisphosphonate medication that reduces bone loss by inhibiting osteoclast activity. It is primarily used to treat conditions characterized by excessive bone resorption, including osteoporosis, Paget's disease, and hypercalcemia of malignancy.
Clodronate Disodium is a bisphosphonate that prevents bone loss by reducing osteoclast activity, used for osteoporosis and other bone conditions.
Key facts at a glance
- RxNorm
- 1546871
- Generic
- Clodronate Disodium
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of osteoporosis, Paget's disease, hypercalcemia of malignancy, and management of bone pain associated with metastatic bone disease.
As a bisphosphonate, Clodronate Disodium binds to bone mineral and is taken up by osteoclasts, inhibiting their activity and reducing bone resorption, which helps maintain bone density.
Take on empty stomach with plain water; remain upright for 30-60 minutes after dose. Avoid calcium-rich foods, supplements, and antacids within 2 hours. May cause GI upset; rare risks include osteonecrosis of the jaw and atypical femoral fractures. Inform your doctor of any kidney problems before starting treatment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy