Clodronic Acid
Clodronic Acid is a bisphosphonate medication used to treat bone disorders including osteoporosis and conditions involving cancer-related bone loss. It works by inhibiting osteoclast cells that break down bone tissue, helping to maintain bone density and reduce fracture risk.
Clodronic Acid is a bisphosphonate that prevents bone loss by inhibiting osteoclasts, used for osteoporosis and bone metastases.
Key facts at a glance
- ATC
- M05BA02
- RxNorm
- 3350
- Generic
- Clodronic Acid
- Class
- atc-m05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of osteoporosis in postmenopausal women and men at increased fracture risk. Also used to reduce skeletal complications from bone metastases in cancer patients and to treat hypercalcemia of malignancy.
As a bisphosphonate, Clodronic Acid binds to bone mineral and is taken up by osteoclasts during bone remodeling. It inhibits osteoclast activity and promotes their apoptosis, thereby reducing bone resorption and increasing bone mineral density over time.
Take on an empty stomach with plain water and remain upright for at least 30-60 minutes after dosing. Common side effects include gastrointestinal symptoms. Rare but serious risks include osteonecrosis of the jaw and hypocalcemia. Ensure adequate calcium and vitamin D intake. Intravenous formulations require careful renal monitoring.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy