Clomethiazole Edisylate
Clomethiazole Edisylate is a sedating medication historically used for short-term treatment of insomnia and sleep disturbances, particularly in elderly patients. It has also been employed in managing alcohol withdrawal symptoms and as pre-operative sedation. The medication works by enhancing the effects of GABA, an inhibitory neurotransmitter in the brain, producing a calming or sedative effect.
Clomethiazole Edisylate is a sedative-hypnotic agent used for insomnia, alcohol withdrawal, and pre-operative sedation.
Key facts at a glance
- RxNorm
- 20802
- Generic
- Clomethiazole Edisylate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for short-term treatment of insomnia and sleep disorders, management of alcohol withdrawal syndrome, and as pre-anesthetic sedation. Has also been used for seizure control in certain contexts.
Acts as a positive allosteric modulator at GABA-A receptors, enhancing inhibitory neurotransmission in the central nervous system. This results in sedative, anxiolytic, and anticonvulsant effects.
Use with caution in patients with respiratory insufficiency, hepatic impairment, or history of substance abuse. May cause dependence with prolonged use. Alcohol should be avoided during treatment. Available by prescription only; use has declined in many countries due to the availability of newer agents.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy