Clomipramine
Clomicalm (clomipramine) is a tricyclic antidepressant medication approved for use in dogs to treat behavioral disorders, particularly separation anxiety. It works by affecting neurotransmitter levels in the brain to help reduce anxiety-related behaviors. This medication requires a veterinary prescription and is typically used as part of a comprehensive behavioral modification program.
Clomicalm is a prescription tricyclic antidepressant for dogs used to treat separation anxiety and other behavioral disorders.
Key facts at a glance
- RxNorm
- 892743
- Generic
- Clomicalm
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Clomicalm is FDA-approved for treating separation anxiety in dogs. It may also be used off-label for other anxiety-related behavioral disorders in dogs as determined by a veterinarian.
As a tricyclic antidepressant, Clomicalm works by inhibiting the reuptake of neurotransmitters, particularly serotonin and norepinephrine, in the brain. This helps regulate mood and reduce anxiety-related behaviors in dogs.
Clomicalm is for canine use only and must be prescribed by a veterinarian. Common side effects may include drowsiness, dry mouth, or gastrointestinal upset. It should not be used in dogs with certain pre-existing conditions. Always follow your veterinarian's dosing instructions and never discontinue treatment abruptly. Clomicalm is often used alongside behavioral training for best results.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy