Clomiphene
Clomiphene is a selective estrogen receptor modulator (SERM) primarily used to treat infertility in women by inducing ovulation. It works by blocking estrogen receptors in the hypothalamus, which stimulates the release of hormones needed for ovulation. It may also be used off-label in men with low testosterone.
Clomiphene is a fertility medication that induces ovulation in women and may increase testosterone in men by acting on estrogen receptors.
Key facts at a glance
- ATC
- G03GB02
- RxNorm
- 2596
- Generic
- Clomiphene
- Class
- atc-g03
- Brands
- Clomid, Milophene
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of anovulatory infertility in women (inability to ovulate), including polycystic ovary syndrome (PCOS); sometimes used in men for hypogonadism or infertility associated with low testosterone.
Blocks estrogen receptors in the hypothalamus, preventing negative feedback and causing increased release of GnRH, FSH, and LH, which stimulates ovarian follicle development and ovulation.
May cause multiple pregnancies (e.g., twins); common side effects include hot flashes, mood swings, and breast tenderness; not recommended for women with liver disease, uterine fibroids, or uncontrolled thyroid/adrenal disorders; should be used under medical supervision with monitoring.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy