Clomipramine
Clomipramine is a tricyclic antidepressant (TCA) primarily used to treat obsessive-compulsive disorder (OCD), depression, and panic disorder. It works by increasing serotonin and norepinephrine levels in the brain, helping to reduce OCD symptoms, improve mood, and decrease anxiety.
Clomipramine is a tricyclic antidepressant mainly prescribed for OCD and depression that works by increasing brain serotonin and norepinephrine levels.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- N06AA04
- RxNorm
- 2597
- Generic
- Clomipramine
- Class
- atc-n06
- Brands
- Caniquell, Calmera, Anafranil, Clomicalm
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, solution, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily prescribed for obsessive-compulsive disorder (OCD), also used for major depressive disorder, panic disorder, and certain chronic pain conditions.
Functions as a serotonin and norepinephrine reuptake inhibitor, increasing these neurotransmitters in the brain to improve mood and reduce obsessive-compulsive symptoms.
May cause drowsiness, dry mouth, weight gain, and sexual dysfunction. Requires careful dose titration and monitoring. Avoid alcohol. May interact with other serotonergic drugs and requires regular follow-up with a healthcare provider.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy