Clonidine Hydrochloride
Clonidine Hydrochloride is an alpha-2 adrenergic agonist that works by reducing sympathetic nervous system activity, leading to decreased blood pressure. It is primarily prescribed for hypertension but is also used off-label for ADHD, anxiety disorders, opioid and alcohol withdrawal symptoms, and menopausal hot flashes.
Clonidine is a blood pressure medication that also helps manage withdrawal symptoms, ADHD, and anxiety by reducing sympathetic nervous system activity.
Key facts at a glance
- RxNorm
- 142432
- Generic
- Clonidine Hydrochloride
- Class
- pin-variant
- Brands
- Kapvay, Duraclon, Onyda, Javadin
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats hypertension (high blood pressure) and is commonly used off-label for ADHD, anxiety, menopausal hot flashes, and management of opioid, alcohol, and nicotine withdrawal symptoms.
As an alpha-2 adrenergic agonist, clonidine stimulates receptors in the brain that reduce sympathetic nervous system outflow, resulting in lowered heart rate and relaxed blood vessels.
May cause drowsiness and dry mouth; should not be stopped abruptly as this can cause rapid blood pressure rise. Avoid alcohol and use caution when operating machinery. Dosage must be tapered gradually under medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy