Cloprostenol
Cloprostenol is a synthetic prostaglandin F2α analog primarily used in veterinary medicine for reproductive management in livestock, particularly cattle and horses. It acts as a potent luteolytic agent, causing regression of the corpus luteum and subsequently inducing estrus, making it valuable for breeding synchronization programs and treatment of certain reproductive disorders.
Cloprostenol is a veterinary prostaglandin analog used for reproductive management in cattle and horses through its luteolytic effects.
Key facts at a glance
- RxNorm
- 2606
- Generic
- Cloprostenol
- Class
- unclassified
- Brands
- Estrumate, Synchsure, Estroplan
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Induction of estrus and estrous synchronization in cattle and horses, treatment of pyometra and chronic endometritis, termination of unwanted pregnancies, and luteolysis in reproductive management programs.
As a prostaglandin F2α analog, cloprostenol causes regression (luteolysis) of the corpus luteum, which removes the source of progesterone and allows estrus to occur. It also has direct effects on smooth muscle in the reproductive tract.
For veterinary use only. Contraindicated in pregnant animals unless pregnancy termination is intended. Should be administered by or under the supervision of a veterinarian. May cause bronchoconstriction; caution in animals with respiratory conditions. Proper handling is essential as it can be absorbed through skin.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy