Clorazepate
Clorazepate is a benzodiazepine medication primarily used to manage anxiety disorders, provide relief from acute alcohol withdrawal symptoms, and serve as adjunctive therapy for partial seizures. It produces calming effects by enhancing the activity of GABA, a neurotransmitter that reduces brain excitability.
Clorazepate is a benzodiazepine used for anxiety, alcohol withdrawal, and seizure management that works by increasing GABA activity in the brain.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- RxNorm
- 2353
- Generic
- Clorazepate
- Class
- unclassified
- Brands
- Tranxene
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Clorazepate is prescribed for the management of anxiety disorders, relief of acute alcohol withdrawal symptoms, and as adjunctive therapy for partial seizures. It may also be used for other conditions as determined by a healthcare provider.
As a benzodiazepine, clorazepate enhances the effect of GABA (gamma-aminobutyric acid), a neurotransmitter that inhibits brain activity, resulting in reduced anxiety, muscle relaxation, and anticonvulsant effects.
This medication carries a risk of dependence with prolonged use and should not be discontinued abruptly. Common side effects include drowsiness, dizziness, and coordination problems. Patients should avoid alcohol and operate vehicles with caution until they know how the medication affects them. Always follow prescribing instructions carefully.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 31, 2026. · Read our editorial policy