Clorazepate Dipotassium
Clorazepate Dipotassium is a long-acting benzodiazepine medication that works by enhancing the activity of GABA, a neurotransmitter that reduces brain activity. It is primarily prescribed for the management of anxiety disorders, as an adjunct treatment for partial seizures, and to help manage symptoms of acute alcohol withdrawal.
Clorazepate Dipotassium is a benzodiazepine used to treat anxiety, seizures, and alcohol withdrawal by enhancing GABA activity in the brain.
Key facts at a glance
- RxNorm
- 2607
- Generic
- Clorazepate Dipotassium
- Class
- pin-variant
- Brands
- Tranxene
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Clorazepate is FDA-approved for the management of anxiety disorders and as adjunctive therapy for partial seizures. It is also used to symptomatic treatment of acute alcohol withdrawal, helping to reduce agitation, tremors, and hallucinations associated with withdrawal.
This medication is a prodrug that is metabolized in the stomach to desmethyldiazepam. It enhances the effects of GABA at GABA-A receptors in the central nervous system, increasing inhibitory signaling and producing sedative, anxiolytic, and anticonvulsant effects.
Clorazepate carries a risk of dependence and withdrawal with prolonged use. It should not be stopped abruptly. Common side effects include drowsiness, dizziness, and impaired coordination. Use with other CNS depressants (especially alcohol) increases the risk of respiratory depression. May impair ability to drive or operate machinery.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy