Coagulation Factor Xiii A-Subunit (Recombinant)
Coagulation Factor XIII A-Subunit (Recombinant) is a replacement therapy that provides the missing A-subunit of Factor XIII to help stabilize blood clots in patients with congenital Factor XIII deficiency. It is used for both routine prophylaxis to prevent bleeding episodes and on-demand treatment of acute bleeding.
A recombinant clotting factor replacement therapy for preventing and treating bleeding in patients with Factor XIII A-subunit deficiency.
Key facts at a glance
- RxNorm
- 1488293
- Generic
- Coagulation Factor Xiii A-Subunit (Recombinant)
- Class
- pin-variant
- Brands
- Tretten
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prophylaxis and treatment of bleeding in patients with congenital Factor XIII A-subunit deficiency, a rare genetic disorder where the body cannot produce enough functional Factor XIII to properly stabilize blood clots.
Provides exogenous recombinant Factor XIII A-subunit, which binds with the endogenous B-subunit to form functional FXIII. Once activated, FXIII cross-links fibrin fibers to strengthen and stabilize blood clots, reducing the risk of bleeding.
Administered via intravenous infusion. Patients should be monitored for signs of allergic reactions and antibodies against Factor XIII. Regular monitoring of trough levels may be needed to maintain adequate protection. Not indicated for patients with Factor XIII B-subunit deficiency.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy