Cobamamide
Cobamamide is a coenzyme form of vitamin B12 used to treat vitamin B12 deficiency and related megaloblastic anemias. It plays a crucial role in DNA synthesis, red blood cell formation, and proper nerve function. This medication is typically prescribed for patients with pernicious anemia, malabsorption issues, or dietary deficiencies.
Cobamamide is a vitamin B12 supplement used to treat anemia and address B12 deficiency by supporting red blood cell production and neurological function.
Key facts at a glance
- ATC
- B03BA04
- RxNorm
- 21373
- Generic
- Cobamamide
- Class
- atc-b03
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- sublingual
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of vitamin B12 deficiency, pernicious anemia, megaloblastic anemia, and general B12 supplementation for patients with malabsorption syndromes, strict vegetarian diets, or impaired absorption due to gastrointestinal conditions.
As a coenzyme form of vitamin B12, cobamamide serves as a cofactor for methylmalonyl-CoA mutase and methionine synthase enzymes, enabling proper DNA synthesis, fatty acid metabolism, and red blood cell formation while maintaining neurological health.
May cause hypersensitivity reactions in patients with cobalt or vitamin B12 allergy. Should be used with caution in patients with Leber's disease. Oral administration requires adequate intrinsic factor; injectable forms bypass this requirement. May interact with certain medications affecting B12 absorption.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy