Cobimetinib
Cobimetinib is a targeted cancer therapy that works as a MEK inhibitor to block signals that drive cancer cell growth and survival. It is primarily used to treat certain types of melanoma with BRAF mutations, typically in combination with other cancer medications.
Cobimetinib is a MEK inhibitor used to treat BRAF-mutant melanoma by blocking cancer cell proliferation signals.
Key facts at a glance
- ATC
- L01EE02
- RxNorm
- 1722365
- Generic
- Cobimetinib
- Class
- atc-l01
- Brands
- Cotellic
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Cobimetinib is indicated for the treatment of BRAF V600 mutation-positive advanced melanoma, usually in combination with a BRAF inhibitor such as vemurafenib or dabrafenib.
Cobimetinib reversibly inhibits MEK1 and MEK2 proteins, which are key regulators of the ERK signaling pathway that controls cellular proliferation, thereby slowing tumor growth.
This medication requires specialist supervision and monitoring. Common side effects may include diarrhea, nausea, rash, and photosensitivity. Patients should avoid prolonged sun exposure and report any vision changes or severe diarrhea promptly.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy