Cobimetinib Fumarate
Cobimetinib fumarate is a targeted therapy medication known as a MEK inhibitor, used in combination with other drugs for the treatment of certain cancers. It is specifically indicated for patients with unresectable or metastatic melanoma that has a BRAF V600E or V600K mutation. The medication works by blocking specific proteins involved in cancer cell growth and survival.
Cobimetinib fumarate is a MEK inhibitor used to treat BRAF-mutated melanoma in combination with other targeted therapies.
Key facts at a glance
- RxNorm
- 1722380
- Generic
- Cobimetinib Fumarate
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of unresectable or metastatic melanoma with BRAF V600E or V600K mutations, used in combination with vemurafenib. It is specifically approved for patients whose tumors test positive for these specific genetic mutations.
Cobimetinib inhibits MEK1 and MEK2 proteins, which are key components of the MAPK signaling pathway. By blocking this pathway, it helps slow the growth and spread of cancer cells that depend on this signaling for survival and proliferation.
May cause serious side effects including heart problems, liver damage, eye problems, and skin reactions. Regular monitoring of cardiac function and liver enzymes is typically required. Effectiveness depends on presence of BRAF mutations, which must be confirmed through testing before treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy