Codeine Phosphate
Codeine Phosphate is an opioid analgesic used to treat mild to moderate pain, coughs, and sometimes diarrhea. It works by binding to opioid receptors in the brain and spinal cord to reduce pain perception and suppress cough reflexes. This medication is typically prescribed when non-opioid pain relievers are insufficient.
An opioid medication for pain relief and cough suppression.
Key facts at a glance
- RxNorm
- 2672
- Generic
- Codeine Phosphate
- Class
- pin-variant
- Brands
- Lortuss EX, M-End Max D, Ascomp, Zodryl DEC, Zodryl DAC, Zodryl AC, Ninjacof XG, Tuxarin, Brontex, Fioricet with Codeine
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Mild to moderate pain (often combined with acetaminophen or aspirin), dry cough suppression, and symptomatic relief of diarrhea.
Codeine binds to mu-opioid receptors in the central nervous system, altering pain perception and the emotional response to pain. As a prodrug, it is metabolized to morphine, which provides the analgesic effect.
Risk of dependence, respiratory depression, and constipation. Not recommended for children under 12. CYP2D6 genetic variations can affect how individuals metabolize codeine, impacting effectiveness and side effects. Avoid alcohol and other CNS depressants. Requires prescription.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy