Codeine Phosphate Anhydrous
Codeine Phosphate Anhydrous is an opioid analgesic used for the treatment of mild to moderate pain and as a cough suppressant. It works by binding to opioid receptors in the brain and central nervous system, where it is metabolized to morphine to produce its analgesic and antitussive effects. This medication is typically prescribed when non-opioid pain relievers are insufficient.
An opioid medication used for pain relief and cough suppression that works by binding to opioid receptors in the brain.
Key facts at a glance
- RxNorm
- 1652891
- Generic
- Codeine Phosphate Anhydrous
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Mild to moderate pain relief, cough suppression (particularly dry, persistent coughs), and occasionally for diarrhea management. Often combined with other medications such as paracetamol or ibuprofen in fixed-dose formulations.
Binds to mu-opioid receptors in the brain and spinal cord, reducing the perception of pain and suppressing the cough reflex. It is a prodrug that is metabolized to morphine and other active metabolites via the CYP2D6 enzyme pathway.
Carries risks of dependence, tolerance, and respiratory depression especially at higher doses. Use with caution in patients with respiratory conditions, hepatic/renal impairment, or history of substance abuse. Not recommended during breastfeeding due to risk of infant sedation. CYP2D6 poor metabolizers may experience reduced efficacy, while ultra-rapid metabolizers may experience enhanced effects and increased risk of toxicity.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy