Codeine Polistirex
Codeine Polistirex is an opioid medication formulated as an extended-release suspension for oral administration. It is primarily used for the management of mild to moderate pain and as a cough suppressant in adults and children over a certain age. As an opioid analgesic, it carries risks of dependence, tolerance, and various side effects that require medical supervision.
Codeine Polistirex is an extended-release opioid used for pain relief and cough suppression, requiring careful medical oversight due to addiction potential.
Key facts at a glance
- RxNorm
- 235412
- Generic
- Codeine Polistirex
- Class
- pin-variant
- Brands
- Tuzistra
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of mild to moderate pain and suppression of cough associated with various respiratory conditions. It is reserved for cases where alternative, non-opioid treatments are inadequate. Prescribing varies by country and specific formulation.
Codeine is a prodrug that is metabolized in the liver by the enzyme CYP2D6 to morphine, its active metabolite. Morphine binds to opioid receptors in the central nervous system, altering the perception of pain and suppressing the cough reflex. The polistirex formulation provides extended-release properties, allowing for less frequent dosing.
Use with caution due to risks of respiratory depression, dependence, and tolerance. Contraindicated in certain populations including children under 12, postoperative patients following tonsillectomy, and individuals with respiratory depression. May interact with other CNS depressants including alcohol. Always follow prescribed dosing and do not crush or chew extended-release formulations. Discuss all current medications and medical history with a healthcare provider before use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy