Colchicine
Colchicine is an anti-inflammatory medication primarily used to treat familial Mediterranean fever (FMF), a hereditary auto-inflammatory condition. It works by interfering with the inflammasome complex in immune cells, thereby reducing inflammatory responses and preventing fever episodes. The medication is also used for acute gout treatment and prevention.
Colchicine is an anti-inflammatory drug used to treat familial Mediterranean fever and gout by reducing inflammation through its effects on neutrophil and monocyte immune cells.
Key facts at a glance
- ATC
- M04AC01
- RxNorm
- 2683
- Generic
- Colchicine
- Class
- atc-m04
- Brands
- Mitigare, Gloperba, Lodoco, Colcrys
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, tablet, capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Familial Mediterranean Fever (FMF) - both for acute attacks and long-term prophylaxis; acute gout flares; pericarditis; and other inflammatory conditions where its anti-inflammatory properties are beneficial.
Colchicine interferes with the intracellular assembly of the inflammasome complex in neutrophils and monocytes, which are key immune cells involved in the inflammatory response. By disrupting this process, it reduces the release of inflammatory mediators and helps control fever and inflammation associated with conditions like FMF.
Colchicine has a narrow therapeutic index, meaning the difference between effective and toxic doses can be small. It requires dose adjustment in patients with renal or hepatic impairment. Common side effects include gastrointestinal symptoms such as diarrhea, nausea, and abdominal pain. Drug interactions are significant, particularly with CYP3A4 and P-glycoprotein inhibitors. Regular monitoring and adherence to prescribed dosing is essential for safe and effective treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy