Collagen
Collagen is a naturally occurring protein used in medical settings primarily as a topical hemostatic agent to help control bleeding during surgical procedures and for the management of wounds. It is available in various forms including sponges, pads, and powders, and may be used in multiple surgical specialties including general surgery, orthopedic surgery, and wound care. Collagen-based hemostatic products work by providing a scaffold for platelet aggregation and clot formation at bleeding sites.
Collagen is a hemostatic agent used to control bleeding during surgery and wound care by promoting clot formation.
Key facts at a glance
- ATC
- unclassified
- RxNorm
- unknown
- Generic
- Collagen
- Class
- atc-b02
- Brands
- —
- Availability
- otc
- Pregnancy
- N
- Lactation
- safe
- Half-life (h)
- 0
- Onset (min)
- 0
- Duration (h)
- 0
- Routes
- oral
- Forms
- powder, capsule, tablet, liquid
- Regions
- United States, European Union, Canada, Australia, Japan, South Korea
- Monitoring
- None
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
7 groupspregnancy
first trimesteruse under medical supervision
consult healthcare provider before use, limited human data available
prenatal monitoring as prescribed
Use with caution and monitor for adverse effects.
pregnancy
third trimesteruse under medical supervision
consult healthcare provider before use
regular prenatal checkups
Use with caution and monitor for adverse effects.
lactation
breastfeedingstandard dosage
generally considered safe, consult physician
none specific
pediatric_age
adolescentsreduced dose recommended
use only under pediatric supervision
growth monitoring if used long-term
Use with caution and monitor for adverse effects.
geriatric
elderlystandard dosage
may benefit joint health and skin elasticity
monitor renal function periodically
renal_impairment
mild to moderatemonitor protein intake
ensure adequate hydration, consult nephrologist
renal function monitoring
Use with caution and monitor for adverse effects.
hepatic_impairment
mild to moderatestandard dosage
generally well tolerated
liver function tests if used long-term
Statistics and clinical data
Commonly used since
General usage information for collagen supplements
Product type
Classification as dietary supplement
Common uses
Common therapeutic uses
Regulatory status
Safety regulatory classification
Collagen hemostatic agents are used to control moderate to severe bleeding during surgical procedures, particularly when traditional methods like suturing or cautery are insufficient. They are also used for management of traumatic wounds, chronic ulcers, and as a matrix for tissue regeneration in various surgical fields.
Collagen provides a negatively charged, structurally intact surface that activates platelets and encourages their aggregation when in contact with blood. This forms a stable platelet plug and accelerates the natural clotting cascade. The collagen matrix also serves as a scaffold for tissue regeneration.
Collagen hemostatic products are typically for topical use only and should not be injected or infused into blood vessels. They should be used with caution in patients with known hypersensitivity to collagen products. Efficacy may be reduced in patients with platelet dysfunction or coagulopathies. Always follow specific product instructions for application and removal.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy