Collagenase
Collagenase is an enzymatic debriding agent used topically to remove dead or damaged tissue from wounds. It works by breaking down collagen in necrotic tissue, allowing for cleaner wound beds that can heal more effectively. This medication is primarily used in the management of chronic wounds such as diabetic foot ulcers and pressure injuries.
Collagenase is an enzyme-based topical treatment that removes dead tissue from wounds to promote healing.
Key facts at a glance
- ATC
- D03BA02
- RxNorm
- 58939
- Generic
- Collagenase
- Class
- atc-d03
- Brands
- Santyl
- Availability
- rx
- Lactation
- unknown
- Routes
- topical
- Forms
- ointment
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of necrotic tissue in chronic wounds including diabetic foot ulcers, pressure ulcers, venous stasis ulcers, and traumatic or surgical wounds where debridement is clinically indicated.
Collagenase is an enzyme derived from Clostridium histolyticum that selectively digests collagen in necrotic tissue. It breaks down the collagen fibers anchoring dead tissue to the wound bed, allowing for gentle removal of devitalized material while preserving healthy granulation tissue.
For topical use only; avoid contact with eyes. Should not be used on wounds with dry eschar or heavy infection. Wound should be kept moist during treatment. Metal ions, certain antiseptics, and acidic pH may reduce enzyme activity. Monitor for signs of infection during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy