Collagenase Clostridium Histolyticum-Aaes
Collagenase Clostridium Histolyticum-Aaes is a topical enzyme preparation derived from Clostridium histolyticum bacteria that breaks down collagen tissue. This pin-variant formulation is designed for localized application to affected skin areas, promoting wound healing and tissue remodeling through enzymatic debridement of collagenous material.
A topical collagen-digesting enzyme used for wound care and dermatological conditions requiring collagen breakdown.
Key facts at a glance
- RxNorm
- 2475861
- Generic
- Collagenase Clostridium Histolyticum-Aaes
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Topical wound care and dermatological conditions involving excessive or abnormal collagen deposition, such as chronic wounds, burn treatment, and certain fibrotic skin conditions requiring enzymatic debridement.
The enzyme collagenase breaks down the collagen matrix in damaged or abnormal tissue, allowing for selective removal of devitalized tissue while preserving healthy structures. This enzymatic debridement supports natural wound healing processes.
For topical use only; avoid contact with eyes and mucous membranes. Should be applied by healthcare professionals familiar with enzymatic debridement techniques. Contraindicated in patients with known hypersensitivity to collagenase or components of the formulation. Effectiveness may be reduced in wounds with heavy microbial contamination.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy